Lipid 5 is an amino lipid that affords efficient mRNA delivery in rodent and primate models. Lipid 5 shows optimal pharmacokinetics and non-toxic side effects. In Vitro Replacement of the linoleic tail with a primary ester-containing lipid tail (Lipid 5) provids increased expression and optimal tissue clearance. The metabolite identification studies with Lipid 5 indicated that hydrolysis of the primary ester is the first step in the metabolism of the lipid. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Clearance of Lipid 5 and MC3 from multiple mouse tissues is measured after dosing 0.05 mg/kg mRNA on days 1, 8, and 15 in CD-1 female mice. Liver and spleen have the highest levels of Lipid 5, however, significantly lower levels than MC3. Lipid 5 is detected in plasma, lung, and kidney, but not in heart . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Liquid
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Lipid 5
CAS number：2089251-33-0 molecular formula：C44H87NO5
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| Chinese alias | 脂质 5 | 十七烷-9-基 8-((2-羟乙基)(8-(壬氧基)-8-氧代辛基)氨基)辛酸酯 | 辛酸8-((2-羟乙基)(8-壬氧基-8-((氧代辛基)氨基)1-辛基壬基酯 | ||
| English alias | LIPIDV 004 | MS-31197 | nonyl 8-[(8-heptadecan-9-yloxy-8-oxooctyl)-(2-hydroxyethyl)amino]octanoate | P4TKZ45P7A | EX-A6658 | BP-26127 | Octanoic acid, 8-[(2-hydroxyethyl)[8-(nonyloxy)-8-oxooctyl]amino]-, 1-octylnonyl ester | Heptadecan-9-yl 8-((2-hydroxye | ||
| CAS number | 2089251-33-0 | molecular formula | C44H87NO5 |
| molecular weight | 710.17 g/mol | Exact mass | - |
| PSA | 76.100 Ų | logp | 15.500 |
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