Mito-apocynin (C11), an orally active mitochondria-targeted triphenylphosphonium (TPP)-based compound, is synthesized by conjugating the Apocynin moiety with a TPP + cation. Mito-apocynin (C11) selectively targets mitochondria, and shows neuroprotective effect. Mito-apocynin (C11) prevents hyposmia and corrects deficits in motor function. In Vivo Mito-apocynin-C11 (3 mg/kg; oral gavage; 3x/wk from 3 months of age until 15 months) markedly improves the coordinated motor function and olfactory function in LRRK2R1441G mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: LRRK2R1441G mice Dosage: 3 mg/kg Administration: Oral gavage; 3x/wk from 3 months of age until 15 months Result: Markedly improved the coordinated motor function and olfactory function. Form:Solid
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Mito-apocynin (C11)
CAS number：1254044-38-6 molecular formula：C37H44BrO4P
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| Chinese alias | 线粒体夹竹桃素 (C11) | ||
| English alias | - | ||
| CAS number | 1254044-38-6 | molecular formula | C37H44BrO4P |
| molecular weight | 663.62 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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