IM176OUT05

IM176OUT05 is a high solubility biguanide. IM176OUT05 activates stem cell metabolism, promotes hair regrowth and increases stemness induction and maintenance during the pluripotent stem cell generation process. IM176OUT0 inhibits mitochondrial electron transport chain ( ETC ) activity with an IC 50 of 3.2 μM. In Vitro IM176OUT05 (0.1-10 μM; 24 hour) inhibits mitochondrial function and reduces the oxygen consumption rate (OCR) as a surrogate of mitochondrial electron transport chain (ETC) activity with an IC 50 of 3.2 μM. IM176OUT05 (10 μM; 6 days) improves the acquisition and maintenance of stem cell pluripotency of mouse and human induced pluripotent stem cells (iPSCs). IM176OUT05 (10 and 100 nM) facilitates the transition of glycolytic metabolism and induces of the expression of glycolysis-related genes and ETC complex enzymes. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo IM176OUT05 (200 μL, 1%; apply to the depilated area, once daily) promotes hair regrowth in mice by stimulating the progression of the hair follicle cycle to the anagen phase and increasing the hair follicle number . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 7-week-old C57BL/6 mice Dosage: 200 μL, 1% Administration: Apply to the depilated area; 200 μL, 1%, once daily Result: Strongly promoted the hair regrowth, especially in female mice. Form:Solid

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