Kuraridine is a prenylated flavonol extract from the roots of Sophora flavescens . Kuraridine has an inhibitory effect on cGMP specific phosphodiesterase type 5 ( PDE5 ) ( IC 50 =0.64 μM) In Vitro Kuraridine shows potent inhibitory activity (IC 50 =0.64 μM) against cGMP PDE5 with 2.0- and 12.9-fold selectivity over PDE3 and PDE4, respectively. Kuraridine induces pronounced chloride inward currents in the absence of GABA. Thecurrents does not exceed 10% of the maximal I GABA induced by a saturating GABA concentration (1 mM). Kuraridine induces a concentration–response curves for I GABA enhancement (EC 50 =4.0±2.4 μM) in Xenopus oocytes expressing GABA A receptors composed of α1, β2, and γ2S subunits. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:PDE5 0.64 μM (IC 50 )
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Kuraridine
CAS number：34981-25-4 molecular formula：C26H30O6
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| Chinese alias | 库拉定 | ||
| English alias | BDBM50366787 | MS-27861 | (2E)-1-[2,4-Dihydroxy-6-methoxy-3-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]phenyl]-3-(2,4-dihydroxyphenyl)-2-propen-1-one | AKOS040761957 | DTXSID501319126 | PIAPWPAWQGDOMN-SXAWMYDMSA-N | HY-121381 | 2-Propen-1-one, 1-[2,4 | ||
| CAS number | 34981-25-4 | molecular formula | C26H30O6 |
| molecular weight | 438.51 g/mol | Exact mass | ≥98% |
| PSA | 107.000 Ų | logp | 6.500 |
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