VU 6008667 is a selective negative allosteric modulator of M5 NAM with IC 50 s of 1.2 μM and 1.6 μM for human M5 and rat M5, respectively. High CNS penetration In Vivo VU 6008667 (1 mg/kg)/PO (3 mg/kg, solution dose) displays a diminished elimination half-life (t 1/2 =2.3 hr) driven by a smaller volume (V ss =7.4 L/kg) and higher clearance (CL p =82 mL/min/kg), with moderate oral bioavailability (17% F) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: RAT (PK study) Dosage: 1 mg/kg; 3 mg/kg Administration: oral adminstration Result: Had a desired short half-life in rat (t 1/2 = 2.3 hr), with moderate oral bioavailability (17% F). Form:Solid IC50& Target:IC50: 1.2 μM (Human M5),1.6 μM (Rat M5)
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VU 6008667
CAS number：2092923-21-0 molecular formula：C24H17ClF2N2O2
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2092923-21-0 | molecular formula | C24H17ClF2N2O2 |
| molecular weight | 438.85 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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