NS3861 is an agonist of nicotinic acetylcholine receptors ( nAChRs ) and binds with high affinity to heteromeric α3β4 nAChR. The binding K i values of 0.62, 25, 7.8, 55 nM for α3β4, α3β2, α4β4, α4β2, respectively. In Vitro NS3861 displays the opposite β-subunit preference and a complete lack of activation at α4-containing receptors in HEK293 cell lines. NS3861 selectively activates α3- but not α4-containing nAChRs and it displays higher efficacy at the α3β2 receptor compared with the α3β4 receptor, with EC 50 s of 1.7 and 0.15 μM for α3β2 and α3β4 receptor, respectively. NS3861 shows high affinity and partial agonist properties in α3β4-expressed nAChRs. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
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NS3861
CAS number：216853-59-7 molecular formula：C12H14BrNS
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 216853-59-7 | molecular formula | C12H14BrNS |
| molecular weight | 284.22 g/mol | Exact mass | ≥99% |
| PSA | 31.500 Ų | logp | 3.100 |
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