Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039. Pomaglumetad methionil hydrochloride has the potential for schizophrenia research In Vitro Pomaglumetad methionil (LY2140023) is a high-affinity peptide transporter 1 (PEPT1) substrate with a K m value of ~30 µM. LY2140023 is active against [ 14 C]Gly-Sar with an IC 50 value of 0.018 mM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Pomaglumetad methionil (LY2140023; orally; 3-300 mg/kg; once daily for 7 days) dose-dependent increases the levels of the dopamine metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Fischer rats (approximately 250 g) Dosage: 3 mg/kg, 10 mg/kg, and 300 mg/kg Administration: Orally; once daily for 7 days Result: Dose-dependent increased the levels of the dopamine metabolites DOPAC and HVA. Form:Solid IC50& Target:mGluR2 mGluR3
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Pomaglumetad methionil hydrochloride
CAS number：635318-26-2 molecular formula：C12H19ClN2O7S2
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| Chinese alias | 盐酸泊马美特甲硫胺 | ||
| English alias | - | ||
| CAS number | 635318-26-2 | molecular formula | C12H19ClN2O7S2 |
| molecular weight | 402.87 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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