Xanomeline (LY 246708) is the potent agonist of muscarinic M1/M4 receptor with antipsychotic-like activity. Xanomeline (LY 246708) increases neuronal excitability. Xanomeline (LY 246708) can be used for the research of schizophrenia In Vitro Xanomeline (LY 246708) (0.1-10 μM; CNS4U) shows an overall increase in the mean firing rate. Xanomeline (LY 246708) shows the M1 receptor is functional in hiPSC derived neurons. Xanomeline (LY 246708) (＞1 μM) has a prolonged engagement with the receptor and produces a persistent receptor activation leading to a sustained suppression of the M-current. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Xanomeline (LY 246708) (0.5-3 mg/kg; s.c.; 1-3 hours) induces salivation and vomiting in some monkeys. Xanomeline (LY 246708) shows functional dopamine antagonism and an antipsychotic-like profile. Xanomeline (LY 246708) inhibits D-amphetamine- and (−)-apomorphine-induced behavior and do not cause extrapyramidal side effects. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Cebus apella monkeysDosage: 0.5-3 mg/kg Administration: s.c.; 1-3 hours Result: Induced salivation and vomiting in some monkeys. Form:Solid IC50& Target:M1/M4
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
Xanomeline tartrate
CAS number：152854-19-8 molecular formula：C18H29N3O7S
overview
compound introduction
Specs
| Chinese alias | 酒石酸沙诺美林 | ||
| English alias | Xanomeline tartrate | UNII-B80W7AUT8R | XANOMELINE (+)-L-HYDROGEN TARTRATE [MI] | XANOMELINE TARTRATE [WHO-DD] | DTXSID00165143 | (2R,3R)-2,3-dihydroxybutanedioic acid;3-hexoxy-4-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazole | D06331 | 3-(4-(HE | ||
| CAS number | 152854-19-8 | molecular formula | C18H29N3O7S |
| molecular weight | 431.50 g/mol | Exact mass | ≥99% |
| PSA | 182.000 Ų | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
