Gallopamil hydrochloride (Methoxyverapamil hydrochloride), a methoxy derivative of Verapamil, is a phenylalkylamine calcium antagonist. Gallopamil hydrochloride inhibits acid secretion in a concentration-dependent manner with an IC 50 of 10.9 μM . Gallopamil hydrochloride is a potent antiarrhythmic and vasodilator agent . In Vivo Gallopamil hydrochloride (Methoxyverapamil hydrochloride; i.v.; 0.2 mg/kg; for 5 min) markedly reduces ventricular tachycardia (VT) and totally prevents fibrillation (VF). Gallopamil significantly reduces systolic and diastolic blood pressure measured 5 min after injection without markedly influencing heart rate. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Wistar rats weighing 290-370 gDosage: 0.2 mg/kg Administration: i.v.; 5 min Result: Markedly reduced VT and totally prevented VF. Form:Solid
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Gallopamil hydrochloride
CAS number：16662-46-7 molecular formula：C28H41ClN2O5
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| Chinese alias | 盐酸加洛帕米 | ||
| English alias | AKOS015994622 | I11594 | (+/-)-Methoxyverapamil HCl | .ALPHA.-ISOPROPYL-.ALPHA.-((N-METHYL-N-HOMOVERATRYL)-.GAMMA.-AMINOPROPYL)-3,4,5-TRIMETHOXYPHENYLACETONITRILE HYDROCHLORIDE | D-600 HYDROCHLORIDE | NCGC00015686-05 | SCHEMBL194931 | Tox21_110196_1 | Met | ||
| CAS number | 16662-46-7 | molecular formula | C28H41ClN2O5 |
| molecular weight | 521.1 g/mol | Exact mass | ≥98% |
| PSA | 73.200 Ų | logp | - |
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