Ganciclovir-d5 是 Ganciclovir 的氘代物。Ganciclovir (BW 759) 是一种核苷类似物和口服抗病毒活性分子，对 CMV 具有抗病毒活性。Ganciclovir 在体外对疱疹病毒 (herpes group) 和其他一些 DNA 病毒也具有抗病毒活性。Ganciclovir 抑制人类疱疹病毒 (HSV 1 型和 2 型，CMV) 和腺病毒血清型1、2、4、6、8、10、19、22 和 28 的体外复制。Ganciclovir 对猫 1 型疱疹病毒 (FHV-1) 的IC50为 5.2 μM。 Ganciclovir-d5 is the deuterium labeled Ganciclovir. Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) .
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Ganciclovir-d5
CAS number：1189966-73-1 molecular formula：C9H8D5N5O4
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Specs
| Chinese alias | - | ||
| English alias | 2-Amino-1,9-dihydro-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy-d5]methyl]-6H-purin-6-one | DHPG-d5 | GCV-d5 | 9-(1,3-dihydroxy-2-propoxymethyl)Guanine-d5 | 2’-NDG-d5 | 2’-Nor-2’-deoxyguanosine-d5 | 2'-Nor-2'-deoxyguanosine-d5 | BW 759-d5 | ||
| CAS number | 1189966-73-1 | molecular formula | C9H8D5N5O4 |
| molecular weight | 260.26 g/mol | Exact mass | ≥98%(CP),≥98 atom% D |
| PSA | - | logp | - |
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