Sangivamycin 是一种对人巨细胞病毒（HCMV）具有活性的细胞毒性嘌呤核苷。桑奇霉素也是一种选择性有效的PKC（蛋白激酶C）抑制剂（IC | 50 | =10μM）。该抑制作用相对于ATP是竞争性的，而相对于组蛋白和脂质辅因子而言是非竞争性的。组蛋白H1蛋白的磷酸化是桑奇霉素防止细胞生长并充当针对多种人类癌症的细胞毒剂的机制。 Sangivamycin 是一种核苷类似物，是蛋白激酶C (PKC) 的有效抑制剂，Ki 为 10 μM。Sangivamycin 对多种人类癌症具有有效的抗增殖活性。 Sangivamycin is a cytotoxic purine nucleoside active against human cytomegalovirus (HCMV). Sangivamycin is also a selective and potent PKC (protein kinase C) inhibitor (IC|50|= 10μM). The inhibition is competitive with respect to ATP and non-competitive with respect to histone and lipid cofactors. The phosphorylation of histone H1 protein is a mechanism by which Sangivamycin prevents the cell growth and acts as cytotoxic agent against a variety of human cancers. Product description Sangivamycin, a nucleoside analog, is a potent inhibitor of protein kinase C (PKC) with an Ki of 10 μM. Sangivamycin has potent antiproliferative activity against a variety of human cancers.
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Sangivamycin
Dangerous GoodsCAS number：18417-89-5 molecular formula：C12H15N5O5
overview
compound introduction
Specs
| Chinese alias | 桑霉素 | 桑吉瓦霉素 | ||
| English alias | BRN 0626355 | 4-Amino-7-beta-D-ribofuranosyl-7H-pyrrolo(2,3-d)pyrimidine-5-carboxamide | 7H-Pyrrolo[2,3-d]pyrimidine-5-carboxamide, 4-amino-7-.beta.-D-ribofuranosyl- | Q27158840 | UNII-L8YQ8Z3T9T | 3nyn | L8YQ8Z3T9T | 4-Amino-7-.beta.-D-ribofuranosyl-7H-p | ||
| CAS number | 18417-89-5 | molecular formula | C12H15N5O5 |
| molecular weight | 309.28 g/mol | Exact mass | ≥98% |
| PSA | 170.000 Ų | logp | -2.500 |
numbering system
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physicochemical properties
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Safety information
pictogram：
GHS06
Signal word：
Danger
Hazard Statement：
H300: 吞咽致命 H310: 与皮肤接触致命 H330: 吸入致命
Statement of Preventive Measures：
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P284: 如果通风不良，请佩戴呼吸防护装置。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持
WGK Germany：
3
RTECS：
UY9355000
Production methods and uses
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MSDS
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