compound introduction
奈马丁 ，最初描述为LL-F28249-a，是一种大环内酯抗生素，具有广谱杀虫和杀线虫活性。奈马丁 与密灭汀A3和阿维菌素抗生素具有结构相似性，区别在于从6,6-1,7-二氧螺环-[5,5]十一烷核心延伸出的不饱和侧链。奈马德丁已证明对绵羊的天然犬感染性蠕虫和抗伊维菌素的捻转血矛线虫有功效。 Nemadectin, initially described as LL-F28249-a, is a macrocyclic lactone antibiotic demonstrating broad-spectrum endectocidal and nematocidal activity. Nemadectin bears structural similarity to the milbemycin and avermectin antibiotics, differing by the unsaturated side-chain extending from the 6,6-spiroketal core of the antibiotic. Nemadectin has demonstrated efficacy against the natural canine-infecting helminths and against ivermectin-resistant|Haemonchus contortus|in sheep.
