Purity:>90%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description： FOXP3 is a transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). It plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome.
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Recombinant Human FOXP3 Protein
CAS number：unknown molecular formula：
overview
compound introduction
Specs
| Chinese alias | Scurfin,重组人FOXP3蛋白 | 重组人 FOXP3 蛋白 | ||
| English alias | Forkhead box protein P3 | Scurfin | ||
| CAS number | unknown | molecular formula | |
| molecular weight | - | Exact mass | 无载体 |
| PSA | - | logp | - |
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MSDS
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