CAS number：656247-17-5 molecular formula：C31H33N5O4
Nintedanib (BIBF 1120)是一种有效的三重血管激酶抑制剂，对VEGFR1/2/3， FGFR1/2/3和PDGFRα/β均有抑制作用，其IC50分别为34 nM/13 nM/13 nM， 69 nM/37 nM/108 nM和59 nM/65 nM。BIBF1120 is a potent kinase inhibitor found to affect VEGF, PDGF, and FGF receptors. Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM. BIBF1120 is a potent kinase inhibitor found to affect VEGF, PDGF, and FGF receptors.
| Chinese alias | - | ||
| English alias | BIBF 1120 | BIBF-1120 | Methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate | BIBF1120 | (Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino}phenylamino)methylene]-2-oxo-2,3-dih | ||
| CAS number | 656247-17-5 | molecular formula | C31H33N5O4 |
| molecular weight | 539.62 g/mol | Exact mass | - |
| PSA | 101.000 Ų | logp | 4.3 |
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