CAS number：1173097-76-1 molecular formula：C18H16N6S2.C2H6O
U0126-EtOH(U-0126)是MEK1和2选择性抑制剂，IC50分别为70nM和60nM，对ΔN3-S218E/S222D MEK的亲和力比PD098059强100倍。 U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM in cell-free assays, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059.
| Chinese alias | - | ||
| English alias | U0126 monoethanolate, >=98% (HPLC), powder | (2Z,3Z)-Bis{amino[(2-aminophenyl)sulfanyl]methylidene}butanedinitrile--ethanol (1/1) | 1173097-76-1 | U0126-EtOH | (2Z,3Z)-2,3-bis(amino((2-aminophenyl)thio)methylene)succinonitrile ethanol | U0126.EtOH | SCHEM | ||
| CAS number | 1173097-76-1 | molecular formula | C18H16N6S2.C2H6O |
| molecular weight | 426.56 g/mol | Exact mass | ≥97% |
| PSA | 222.000 Ų | logp | - |
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