溶葡球菌酶 来源于模仿葡萄球菌

溶葡萄球菌酶是一种锌金属酶，主要以酶原的形式分泌出来。它可用作抗金黄色葡萄球菌剂，在pH4和5℃时高度稳定。 用途： 来自拟葡萄球菌的溶葡球菌酶被用于评估lytM（一种独特的金黄色葡萄球菌自溶基因）的分子克隆、测序和表达。 它还被用于研究金黄色葡萄球菌中编码肽聚糖水解酶活性的基因的序列分析。 生化机理： 一种蛋白复合体，对葡萄球菌属（包括金黄色葡萄球菌）具有高度特异性裂解活性。 溶葡萄球菌酶具有抗金黄色葡萄球菌的裂解作用，可用于治疗耐抗生素的葡萄球菌感染。它具有甘氨酰甘氨酸内肽酶、内-β-N-乙酰葡萄糖胺酶和N-乙酰胞壁酰-L-丙氨酸酰胺酶等多种酶的特性。溶葡萄球菌酶还可用于食品防腐和临床实验室的快速筛查。 通过与金黄色葡萄球菌的膜相关Trap蛋白的C′ 端结合，溶葡球菌酶（金黄色葡萄球菌表达的一种金属内肽酶）的抗微生物活性得到增强。 Product description： Lysostaphin, a zinc metalloenzyme, is mainly secreted as a proenzyme. It acts as an anti-staphylococcal agent and is highly stable at pH 4 and 5°C. Application： Lysostaphin from Staphylococcus simulans has been used in a study to assess molecular cloning, sequencing, and expression of lytM, a unique autolytic gene of Staphylococcus aureus. It has also been used in a study to investigate the sequence analysis of a Staphylococcus aureus gene encoding a peptidoglycan hydrolase activity. Biochemical/Physiological Effects： A protein complex with highly specific lytic activity against Staphylococcus species, including Staphylococcus aureus. Lysostaphin possesses a lytic action against Staphylococcus aureus, which is used to treat antibiotic-resistant staphylococcal infections. It has the properties of enzymes, such as glycylglycine endopeptidase, endo-β-N-acetyl glucosamidase and N-acetyl muramyl-L-alanine amidase. Lysostaphin is also used as a preservative in food industry and in clinical labs for rapid screening. The antimicrobial activity of lysostaphin, a metalloendopeptidase expressed by Staphylococcus simulans, is enhanced by binding to the C′ terminus of the membrane-associated Trap protein of Staphylococcus aureus.

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