(Rac)-Lanicemine ((Rac)-AZD6765) is the racemate of Lanicemine. Lanicemine (AZD6765) is a low-trapping NMDA channel blocker ( K i of 0.56-2.1 μM for NMDA receptor ; IC 50 s of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively). Antidepressant effects In Vivo Lanicemine produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects . Lanicemine (3, 10 or 30 mg/kg; intraperitoneal) not only engages brain circuits involved in the generation of gamma- electroencephalography (EEG), but also influences these networks independent of the broader systems-level disruptions typical of ketamine . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Sprague-Dawley rats Dosage: 3, 10 or 30 mg/kg Administration: Intraperitoneal Result: Produced pronounced dose-dependent elevations in spontaneous gamma-band EEG, but only gamma changes for Ketamine were tightly coupled to increases in locomotor activity. Form:Liquid IC50& Target:NMDA receptor
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(Rac)-Lanicemine
CAS number：61890-25-3 molecular formula：C13H14N2
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| Chinese alias | (Rac)-兰妮丝胺 | ||
| English alias | - | ||
| CAS number | 61890-25-3 | molecular formula | C13H14N2 |
| molecular weight | 198.26 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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