compound introduction
Xevinapant (AT406, ARRY-334543, Debio1143, SM-406)是一种有效的，拟Smac的IAP(通过E3泛素连接酶起作用的凋亡蛋白抑制剂)拮抗剂，与XIAP-BIR3， cIAP1-BIR3和cIAP2-BIR3结合，Ki为66.4 nM， 1.9 nM和5.1 nM，比作用于Smac AVPI肽亲和力高50到100倍.
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AT406 (SM-406)
CAS number：1071992-99-8 molecular formula：C32H43N5O4
overview
Specs
| Chinese alias | - | ||
| English alias | Iap inhibitor AT-406 | Debio 1143 | D 1143 | SM 406 | 1071992-99-8 | EX-A104 | GTPL7729 | NSC764757 | NSC-764757 | (5S,8S,10aR)-N-benzhydryl-5-((S)-2-(methylamino)propanamido)-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide | | ||
| CAS number | 1071992-99-8 | molecular formula | C32H43N5O4 |
| molecular weight | 561.71 g/mol | Exact mass | - |
| PSA | 111.000 Ų | logp | 3.100 |
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