CAS number：475488-23-4 molecular formula：C28H31N5O
NVP-ADW742是一种IGF-1R抑制剂，IC50为0.17 μM，作用于IGF-1R比作用于InsR效果强16倍以上；对HER2， PDGFR， VEGFR-2， Bcr-Abl和c-Kit几乎没有活性。An IGF-1R inhibitor with IC50 of 0.17 μM NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit. An IGF-1R inhibitor with IC50 of 0.17 μM
| Chinese alias | - | ||
| English alias | 5-(3-Benzyloxyphenyl)-7-[trans-3-[(pyrrolidin-1-yl)methyl]cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine | AS-56233 | 5-(3-phenylmethoxyphenyl)-7-[3-(pyrrolidin-1-ylmethyl)cyclobutyl]pyrrolo[2,3-d]pyrimidin-4-amine | GSK-552602A | GSK-552602-A | SB19377 | | ||
| CAS number | 475488-23-4 | molecular formula | C28H31N5O |
| molecular weight | 453.58 g/mol | Exact mass | ≥99% |
| PSA | 69.200 Ų | logp | 4.600 |
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