CAS number：60477-38-5 molecular formula：C15H13N3O2S
Pifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form p53 inhibitor. Pifithrin-α, p-Nitro, Cyclic is one order magnitude more active than Pifithrin-α in protecting cortical neurons exposed to Etoposide (ED50=30 nM). Pifithrin-α, p-Nitro, Cyclic behaves as a p53 posttranscriptional activity inhibitor. Pifithrin-α, p-Nitro, Cyclic do not prevent p53 phosphorylation on the S15 residue.
| Chinese alias | 5,6,7,8-四氢-2-(4-硝基苯基)-咪唑[2,1-b]苯并噻唑 | ||
| English alias | 5,6,7,8-Tetrahydro-2-(4-nitrophenyl)-imidazo[2,1-b]benzothiazole | ||
| CAS number | 60477-38-5 | molecular formula | C15H13N3O2S |
| molecular weight | 299.35 g/mol | Exact mass | ≥99% |
| PSA | 91.400 Ų | logp | 4.400 |
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