CAS number：869998-49-2 molecular formula：C32H32F3N3O2
CAY10500是一种TNFα抑制剂，可防止与TNF Receptor 1（TNFR1）结合。该化合物与具有生物活性的TNFα三聚体结合，并促进单个亚基的加速置换，从而迅速使细胞因子失活。在基于细胞的测定中，CAY10500抑制TNFα介导的IKB降解刺激。 CAY10500 is a TNFα inhibitor that prevents binding to the TNF Receptor 1 (TNFR1). The compound binds to the biologically active TNFα trimer and promotes accelerated displacement of a single subunit to rapidly inactivate the cytokine. In a cell based assay, CAY10500 inhibited TNFα-mediated stimulation of IKB degradation.
| Chinese alias | - | ||
| English alias | HY-111255 | AKOS040738946 | Q27453438 | SCHEMBL1270919 | CAY10500 | 6,7-dimethyl-3-((methyl-(2-(methyl-(1-(3-trifluoromethyl-phenyl)-1h-indol-3-ylmethyl)-amino)-ethyl)-amino)-methyl)-chromen-4-one | JZNXLPPJRFFECJ-UHFFFAOYSA-N | BDBM50373071 | NCGC0038670 | ||
| CAS number | 869998-49-2 | molecular formula | C32H32F3N3O2 |
| molecular weight | 547.6 g/mol | Exact mass | - |
| PSA | 37.700 Ų | logp | 6.300 |
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