CAS number：340267-36-9 molecular formula：C17H12F3NO3S
CAY10404是迄今为止报道的对COX-2最具选择性的抑制剂之一，其选择性指数（SI; SI = IC50 COX-1 / IC50 COX-2）大于500,000。（COX-1 IC50大于500 mM，COX-2 IC50小于1 nM。）作为参考点，塞来昔布的SI约为400。因此，CAY10404的SI比第一代的SI大几倍。具有选择性的COX-2抑制剂，与第二代选择性COX-2抑制剂（如valdecoxib和etoricoxib）的SI相当。 CAY10404 is one of the most selective inhibitors of COX-2 which has been reported to date, with a selectivity index (SI; SI = IC50 COX-1/IC50 COX-2) of >500,000. (The COX-1 IC50 is >500 mM, and COX-2 IC50 is
| Chinese alias | 3-(4-(甲基磺酰基)苯基)-4-苯基-5-(三氟甲基)异恶唑 | ||
| English alias | CAY10404 | 3-(4-methylsulfonylphenyl)-4-phenyl-5-trifluoromethylisoxazole | ||
| CAS number | 340267-36-9 | molecular formula | C17H12F3NO3S |
| molecular weight | 367.34 g/mol | Exact mass | ≥98% |
| PSA | 68.600 Ų | logp | 3.800 |
No numbering system information yet
No physical and chemical property information yet
No safety information yet
No production method and use information yet
No upstream information yet
No downstream information yet
