CAS number：1883863-52-2 molecular formula：C34H31ClN8O5S
dBET57 是一种基于PROTAC技术的新颖、有效且具有选择性的 BRD4BD1 的降解剂，其DC50/5h值为500 nM。dBET57在 BRD4BD2 上无效。 Information dBET57 is a novel, potent and selective degrader of BRD4 BD1 based on the PROTAC technology with DC 50/5h of 500 nM. dBET57 is inactive on BRD4 BD2 . Targets BRD4 BD1 (Cell-free assay) 500 nM(DC50)
| Chinese alias | - | ||
| English alias | 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide,4-(4-chlorophenyl)-N-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethyl]-2,3,9-trimethyl-,(6S)- | ||
| CAS number | 1883863-52-2 | molecular formula | C34H31ClN8O5S |
| molecular weight | 699.18 g/mol | Exact mass | 10mM in DMSO |
| PSA | 196.000 Ų | logp | 3.099 |
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