CAS number：882290-02-0 molecular formula：C15H8Cl2FN3O
SC99是一种口服活性的选择性STAT3抑制剂，通过对接JAK2的ATP结合囊靶向JAK2-STAT3通路；SC99也抑制JAK2和STAT3的磷酸化，但对其他与STAT3信号通路相关的激酶无影响。 Information SC99 is an orally active, selective inhibitor of STAT3 that docks into the ATP-binding pocket of JAK2 and inhibits phosphorylation of JAK2 and STAT3. SC99 inhibits platelet activation, aggregation and displays potent anti-myeloma, anti-thrombotic activities.
| Chinese alias | N'-(3-氯-4-氟苯基)-2-(4-氯苯基)-2-氧代乙烷亚肼基氰化物 | ||
| English alias | N'-(3-Chloro-4-fluorophenyl)-2-(4-chlorophenyl)-2-oxoacetohydrazonoyl cyanide | ||
| CAS number | 882290-02-0 | molecular formula | C15H8Cl2FN3O |
| molecular weight | 336.15 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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