说明： Liproxstatin-1是一种有效的ferroptosis抑制剂，IC50为22 nM。 应用： Liproxstatin-1 在细胞活力试验和脂质过氧化测定中用作细胞死亡抑制剂。 Information Liproxstatin-1 Liproxstatin-1 is a potent ferroptosis inhibitor with an IC50 of 22 nM. Targets ferroptosis (Cell-free assay) 22 nM In vitro Liproxstatin-1 is able to inhibit ferroptosis in the low nanomolar range and inhibit the growth of Gpx4 −/− cells with IC50 of 22 nM. Liproxstatin-1 (50 nM) completely prevents lipid peroxidation in Gpx4 −/− cells. Liproxstatin-1 (200 nM) protects against FINs, such as BSO (10 µM), erastin (1 µM) and RSL3 (0.5 µM), in a dose dependent manner, whereas it fails to rescue cell death induced by staurosporine (0.2 µM) and H 2 O 2 (200 µM). In vivo Liproxstatin-1 remarkably extends survival compared with the vehicle-treated group, delays ferroptosis in tubular cells, and mitigates tissue injury in ischaemia/reperfusion-induced liver injury. Cell Research(from reference) Cell lines：Gpx4 −/− cells Concentrations：~200 nM Incubation Time：~72 h
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Liproxstatin-1
CAS number：950455-15-9 molecular formula：C19H21ClN4
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| Chinese alias | N-[(3-氯苯基)甲基]-螺 [哌啶-4,2' (1'H)-喹喔啉]-3'-胺, N-[(3-氯苯基)甲基] 螺-[4H-喹喔啉-3,4'-哌啶 ]-2-胺 | ||
| English alias | N-[(3-chlorophenyl)methyl]-spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine | N-[(3-chlorophenyl)methyl]spiro[4H-quinoxaline-3,4'-piperidine]-2-amine | ||
| CAS number | 950455-15-9 | molecular formula | C19H21ClN4 |
| molecular weight | 340.85 g/mol | Exact mass | - |
| PSA | 48.500 Ų | logp | 2.598 |
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