CAS number：2417302-07-7 molecular formula：C23H26F3N6OP
SY-5609 (CDK7-IN-3) 是一种高选择性，非共价的 CDK7 抑制剂，KD 为 0.065 nM。SY-5609 对 CDK2 (Ki=2600 nM)，CDK9 (Ki=960 nM)，CDK12 (Ki=870 nM) 具有较弱的抑制作用。SY-5609 诱导肿瘤细胞凋亡并具有抗肿瘤活性。 SY-5609 (CDK7-IN-3) is a highly selective, noncovalent CDK7 inhibitor with a KD of 0.065 nM. SY-5609 shows poor inhibition on CDK2 (Ki=2600 nM), CDK9 (Ki=960 nM), CDK12 (Ki=870 nM). SY-5609 induces apoptosis in tumor cells and has antitumor activity.
| Chinese alias | - | ||
| English alias | CDK7-IN-3 | BDBM50583929 | 1H-Indole-6-carbonitrile, 7-(dimethylphosphinyl)-3-(2-(((3S)-6,6-dimethyl-3-piperidinyl)amino)-5-(trifluoromethyl)-4-pyrimidinyl)- | JDJOUBVVSQDIRC-AWEZNQCLSA-N | EN300-37407429 | 1H-Indole-6-carbonitrile, 7-(dimethylphosphinyl) | ||
| CAS number | 2417302-07-7 | molecular formula | C23H26F3N6OP |
| molecular weight | 490.46 g/mol | Exact mass | - |
| PSA | 106.000 Ų | logp | 2.700 |
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