Humanin, an anti-apoptotic peptide of 24 amino acids , is a Bax inhibitor. Humanin prevents the translocation of Bax from cytosol to mitochondria, blocks Bax from the inactive to active conformation. Humanin is a mitochondria-associated peptide with a neuroprotective effect against AD-related neurotoxicity. Humanin also improves overall insulin sensitivity in animal. Humanin are related to aging Humanin analogue, in which the serine at position 14 is replaced by glycine, names HNG . In Vitro Humanin (40 nM, rhodamine-conjugated; 30 min) inhibits cell death induced by Bax protein in wild-type HCT116 cells. Humanin (100 μM; 10 min) blocks Bax association with isolated mitochondria, and suppresses cytochrome c release in wild-type HCT116 cells. Humanin reduces half apoptosis induced by 0.2 mM STS. Humanin fails to suppress apoptosis in Bax-deficient HCT116 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Humanin (0.375 mg/kg/hr; i.v.) increases peripheral insulin sensitivity in Zucker diabetic fatty (ZDF) rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Bax
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Humanin
CAS number：330936-69-1 molecular formula：C119H204N34O32S2
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| Chinese alias | 人类蛋白 | ||
| English alias | Protein Humanin (human) | T lymphocyte activation-associated protein PRO86272 (human) | HUMANIN TRIFLUOROACETATE | GTPL1047 | Humanin (human) trifluoroacetate (H-Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-A | ||
| CAS number | 330936-69-1 | molecular formula | C119H204N34O32S2 |
| molecular weight | 2687.23 g/mol | Exact mass | ≥95% |
| PSA | 1090.000 Ų | logp | -6.700 |
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