CAS number：582314-48-5 molecular formula：C17H15Cl2NO2
Apoptosisinducer 34 (Compound 4) 是一种通过直接激活基础凋亡机制来诱导细胞凋亡的小分子化合物。Apoptosisinducer 34 可促进Apaf-1的寡聚化形成成熟的凋亡小体，从而激活caspase-9和caspase-3。Apoptosisinducer 34 在 Jurkat 细胞中通过增强cytochrome c依赖性凋亡信号途径显著激活凋亡通路，并诱导PARP裂解和染色体 DNA 片段化。此外，Apoptosisinducer 34 对正常细胞具有较低毒性，展现出选择性靶向癌细胞的潜力。Apoptosisinducer 34 有望用于与凋亡通路相关的癌症研究。
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| CAS number | 582314-48-5 | molecular formula | C17H15Cl2NO2 |
| molecular weight | 336.22 g/mol | Exact mass | - |
| PSA | 38.300 Ų | logp | 4.600 |
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