compound introduction
IAXO-102 是一种靶向MD-2和CD14共同受体的 TLR4 的拮抗剂。IAXO-102 可抑制 MAPK 和p65 NF-κB 磷酸化，并下调TLR4依赖性促炎蛋白的表达。IAXO-102 可抑制实验性腹主动脉瘤 (AAA) 的发展。 Product description： IAXO-102 is an antagonist of TLR4 targeting both MD-2 and CD14 co-receptors. IAXO-102 inhibits MAPK and p65 NF-κB phosphorylation and downregulates the expression of TLR4 dependent proinflammatory proteins. IAXO-102 inhibits experimental abdominal aortic aneurysm (AAA) development. Targets TLR4 ; MAPK ; NF-κB
