CAS number：1542135-76-1 molecular formula：C19H29N5O3
LML134 (化合物 18b) 是一种具有口服活性，高选择性 H3R (组胺 3 受体) 反向激动剂，对 hH3R 的 cAMP 和 bdg 的 Kis 分别为 0.3 nM 和 12 nM。LML134 快速穿透大脑，导致高 H3R 占有率，并以快速的动力学特征使其目标脱离。LML134 用于治疗过度睡眠障碍。 LML134 is an orally active and highly selective inverse agonist of Histamine 3 receptor (H3R) with Ki of 0.3 nM and 12 nM for hH3R cAMP and hH3R bdg, respectively. LML134 has the potential for excessive sleep disorders.
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| CAS number | 1542135-76-1 | molecular formula | C19H29N5O3 |
| molecular weight | 375.47 g/mol | Exact mass | ≥98% |
| PSA | 68.700 Ų | logp | 0.600 |
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