compound introduction
G150 是一种高选择性的 human cyclic GMP-AMP synthase h-cGAS 抑制剂 IC50 值为 10.2 nM。G150 可抑制 dsDNA 引发的干扰素表达，可用于炎症的研究。 Information G150 G150 is a potent and highly selective human cyclic GMP-AMP synthase (cGAS) inhibitor with IC50 of 10.2 nM. Targets h-cGAS (Cell-free assay) 10.2 nM In vitro The most potent h-cGAS-specific derivative with 2-amino pyridine (G150) shows inhibitory activity in THP1 cells and primary human macrophages while a complete absence of off-target effect on a diverse range of sensors. G150 also shows no substantial cellular toxicity. Cell Research(from reference) Cell lines：THP1 cells, primary macrophage cells Concentrations：10 μM and 5 μM Incubation Time：1 h
