compound introduction
ATI-2341 TFA是一种有效的 C-X-C 趋化因子受体 4 型 (CXCR4) 功能选择性变构激动剂，其作为偏向配体起作用，有利于 Gα1激活而不是 Gα13。ATI-2341 TFA激活抑制性异源三聚体 G 蛋白 (Gi) 以促进 cAMP 产生的抑制并诱导钙动员。ATI-2341TFA 是一种有效骨髓多形核中性粒细胞 (PMNs) 和造血干细胞和祖细胞 (HSPCs) 动员剂。 Biochemical Mechanism ATI-2341 is a potent and selective allosteric agonist of chemokine CXC-type receptor 4 (CXCR4) that functions as a biased ligand, favoring Gαi activation over Gα13. ATI-2341 does not promote β-arrestin recruitment. ATI-2341 promotes the mobilization of PMNs and HSPCs in the peripheral circulation of both mice and monkeys.
