diABZI STING agonist-1 is a selective stimulator of interferon genes (STING) receptor agonist, with EC 50 s of 130, 186 nM for human and mouse, respectively. In Vitro diABZI STING agonist-1 is a selective stimulator of interferon genes (STING) receptor agonist, with EC 50 s of 130, 186 nM for human and mouse, respectively. At a concentration of 1 μM, diABZI STING agonist-1 (compound 3) demonstrates high selectivity against more than 350 kinases tested. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo diABZI STING agonist-1 (subcutaneous injection; 2.5 mg/kg) induces STING-dependent activation of type-I interferon and pro-inflammatory cytokines in vivo . diABZI STING agonist-1 (intravenous injection; 3 mg/kg) exhibits systemic exposure with a half-life of 1.4 h and achieves systemic concentrations greater than the half-maximal effective concentration (EC 50 ) for mouse STING (200 ng/ml) . diABZI STING agonist-1 (intravenous injection; 1.5 mg/kg; days 1, 4 and 8; 43 days) results in significant tumour growth inhibition and significantly improves survival (P Form:Solid IC50& Target:STING
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diABZI STING agonist-1
CAS number：2138299-33-7 molecular formula：C42H51N13O7
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| Chinese alias | diABZI STING 激动剂-1 | ||
| English alias | compound 3 [PMID: 30405246] | diABZI | diABZI STING agonist-1 | diABZI STING agonist-1 Tautomerism | HY-112921 | 1-[(2E)-4-[5-carbamoyl-2-(1-ethyl-3-methyl-1H-pyrazole-5-amido)-7-[3-(morpholin-4-yl)propoxy]-1H-1,3-benzodiazol-1-yl]but-2-en-1-yl]-2-(1-ethy | ||
| CAS number | 2138299-33-7 | molecular formula | C42H51N13O7 |
| molecular weight | 849.94 g/mol | Exact mass | ≥99% |
| PSA | 247.000 Ų | logp | 1.900 |
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