E7766 diammonium salt is a macrocycle-bridged STING agonist with a K d of 40 nM. E7766 diammonium salt shows potent pan-genotypic and antitumor activities. In Vitro E7766 diammonium salt inhibits four human STING variants, human wild-type, HAQ, AQ and REF STING proteins, with EC 50 values of 1 μM, 2.2 μM, 1.2 μM and 4.9 μM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo In murine colon cancer model, a single intratumoral injection of 10 mg/kg E7766 diammonium salt in the subcutaneous tumor. E7766 diammonium salt is shown to have potent antitumor activity with long lasting immune memory response in a mouse liver metastatic tumor model . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
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E7766 diammonium salt
CAS number：2242635-03-4 molecular formula：C24H32F2N12O8P2S2
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| Chinese alias | E7766 二铵盐 | ||
| English alias | - | ||
| CAS number | 2242635-03-4 | molecular formula | C24H32F2N12O8P2S2 |
| molecular weight | 780.66 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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