STING agonist-16 (1a) is a specific stimulator of interferon genes ( STING ) agonist. STING agonist-16 (1a) can be used as a potential antiviral and antitumor tool. In Vitro STING agonist-16 (1a) (0-100 μM, 6 h) can promote mRNA expression of IFNβ, CXCL-10 and IL-6 in a dose-dependent manner with no significant cytotoxic effect up to 100 μM in human myeloid leukemia mononuclear cells (THP1). STING agonist-16 (1a) (50 μM, 2 h) significantly induces the phosphorylation of STING, TANK-binding kinases1 (TBK1) and interferon regulatory factor 3 (IRF3) in THP1 cells. STING agonist-16 (1a) activates secretory alkaline phosphatase (SEAP) in a dose-dependent manner with an EC 50 value of 16.77 μM while 2'3'-cGAMP acts with an EC 50 value of 9.212 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
STING agonist-16
CAS number：652142-94-4 molecular formula：C19H11Cl2N5O
overview
compound introduction
Specs
| Chinese alias | STING 激动剂-16 | ||
| English alias | - | ||
| CAS number | 652142-94-4 | molecular formula | C19H11Cl2N5O |
| molecular weight | 396.23 g/mol | Exact mass | - |
| PSA | - | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
