compound introduction
AF3485 是一种人类 mPGES-1 抑制剂，显示出体外和体内的抗肿瘤活性。AF3485 通过减少 PGE2 产生，抑制EGFR信号传导，降低VEGF和 FGF-2 的表达，进而抑制肿瘤相关的血管生成。AF3485 在带有人类 A431 异种移植瘤的小鼠中，通过亚慢性给药减少了肿瘤生长。
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n-[9-(2-Hydroxyethyl)-9h-carbazol-3-yl]-2-(trifluoromethyl)benzamide
CAS number：1195786-61-8 molecular formula：C22H17F3N2O2
overview
Specs
| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 1195786-61-8 | molecular formula | C22H17F3N2O2 |
| molecular weight | 398.38 g/mol | Exact mass | - |
| PSA | 54.300 Ų | logp | 4.300 |
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