Description Hmb protection of amide bonds has been shown to inhibit aggregation of ′difficult′ peptides, thereby leading to products of increased purity [1-6]. Retention of Hmb groups on the cleaved peptide can greatly improve the solubility of protected peptide fragments [7, 8] and otherwise intractable sequences [9-11]. Furthermore, using a Hmb-protected derivative for incorporation of the residue linked to the carboxyl group of Asp or Asn residues has been found to suppress formation of aspartimide and piperidide related by-products [12-14]. For a comparison of the efficiency of Hmb and pseudoprolines in preventing aggregation, see [15].The product number for this product was previously 04-12-1187.. Description Hmb protection of amide bonds has been shown to inhibit aggregation of ′difficult′ peptides, thereby leading to products of increased purity [1-6]. Retention of Hmb groups on the cleaved peptide can greatly improve the solubility of protected peptide fragments [7, 8] and otherwise intractable sequences [9-11]. Furthermore, using a Hmb-protected derivative for incorporation of the residue linked to the carboxyl group of Asp or Asn residues has been found to suppress formation of aspartimide and piperidide related by-products [12-14]. For a comparison of the efficiency of Hmb and pseudoprolines in preventing aggregation, see [15].The product number for this product was previously 04-12-1187..
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Fmoc-(FmocHmb)Phe-OH
CAS number：148515-88-2 molecular formula：C47H39NO8
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | Fmoc-(FmocHmb)Phe-OH, N-α-Fmoc-N-α-(2-Fmoc-oxy-4-methoxybenzyl)-L-phenylalanine | ||
| CAS number | 148515-88-2 | molecular formula | C47H39NO8 |
| molecular weight | - | Exact mass | Reagent Grade |
| PSA | - | logp | - |
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148515-88-2 | Fmoc-(FmocHmb)Phe-OH Novabiochem®.pdf
