Hyaluronan biotin sodium salt

透明质酸（Hyaluronic Acid，HA），俗称玻尿酸，最早是Karl Meyer在牛眼玻璃体中发现的，随后的研究发现HA广泛存在于如结缔组织、皮肤组织以及神经组织中。HA是由D-葡萄糖醛酸（GlcUA）和N-乙酰葡萄糖胺（GlcNAc）组成的二糖单位（GlcUAβ1-3GlcNAc）通过β-1,4糖苷键重复连接而成的非硫酸化、不与蛋白共价结合的结构最为简单的GAGs。HA分子量通常远远大于其它糖胺聚糖（100-1,000 kDa），具有优越的亲水性和粘弹性，在再生医学领域、药物递送系统，特别是化妆品领域均有广泛应用。此外，HA还参与许多重要的生理学病理学过程，如创伤修复、受精作用、细胞的增殖与迁移、心血管疾病及癌症发生等。 Hyaluronic acid (HA), commonly known as hyaluronic acid, was first discovered by Karl Meyer in bovine vitreous humor. Subsequent studies have found that HA is widely present in connective tissue, skin tissue, and nerve tissue. HA is the simplest non sulfated GAGs composed of disaccharide units (GlcUA β 1-3GlcNAc) composed of D-glucuronic acid (GlcUA) and N-acetylglucosamine (GlcNAc), which are repeatedly linked by β -1,4-glycosidic bonds. The molecular weight of HA is usually much larger than other glycosaminoglycans (100-1000 kDa), and it has superior hydrophilicity and viscoelasticity. It is widely used in the fields of regenerative medicine, drug delivery systems, and especially cosmetics. In addition, HA is also involved in many important physiological and pathological processes, such as wound repair, fertilization, cell proliferation and migration, cardiovascular disease, and cancer occurrence.

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