CAS number：879085-55-9 molecular formula：C19H14Cl2N2O3S
Vismodegib (GDC-0449)是一种有效的，新型的，特异性的hedgehog抑制剂，IC50为3 nM。GDC-0449也抑制P-gp作用，IC50为3.0μM。A potent hedgehog (Hh) signaling pathway inhibitor. Vismodegib (GDC-0449) is a potent, novel and specific hedgehog inhibitor with IC50 of 3 nM and also inhibits P-gp with IC50 of 3.0 μM. A potent hedgehog (Hh) signaling pathway inhibitor.
| Chinese alias | 维莫德吉(GDC-0449) | 维斯莫德吉 (GDC-0449) | ||
| English alias | Vismodegib (USAN/INN) | 2-Chloro-N-(4-chloro-3-(pyridin-2-yl)-phenyl)-4-(methylsulfonyl)benzamide | 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide | 2-Chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-4-(methylsulfonyl)benzamide | BCP900 | ||
| CAS number | 879085-55-9 | molecular formula | C19H14Cl2N2O3S |
| molecular weight | 421.31 g/mol | Exact mass | - |
| PSA | 84.500 Ų | logp | 3.8 |
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