CAS number：941678-49-5 molecular formula：C17H18N6
Ruxolitinib (INCB018424)是第一个应用于临床的、有效的、选择性的JAK1/2抑制剂，IC50为3.3 nM/2.8 nM。作用于JAK1， JAK2与 作用于JAK3相比，选择性强130倍多。An inhibitor of JAK1, JAK2, and JAK3. INCB018424 is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3. An inhibitor of JAK1, JAK2, and JAK3.
| Chinese alias | 鲁索替尼 | 鲁索利替尼 | 卢索替尼 | 芦可替尼 | ||
| English alias | INCB 018424 | INCB018424 | INCB-018424 | (betaR)-beta-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile | DB08877 | UPCMLD-DP017:001 | CHEBI:66919 | BRD-K53972329-001-02-1 | DTXCID40163421 | CCG-264889 | INCB 18424 | TRIMIPRAMIN | ||
| CAS number | 941678-49-5 | molecular formula | C17H18N6 |
| molecular weight | 306.37 g/mol | Exact mass | - |
| PSA | 83.200 Ų | logp | 2.100 |
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