compound introduction
PF-04859989 hydrochloride 是一种可透过血脑屏障的，不可逆的犬尿氨酸转氨酶 KAT II 抑制剂，对 hKATⅡ 和 rKATⅡ 的 IC50 分别为 23 和 263 nM。PF-04859989 hydrochloride 对 KATⅡ 的选择性高于人 KATⅠ、KATⅢ 和 KATⅣ (IC50 分别为22、11和 >50 μM)。 PF-04859989 hydrochloride is a blood-brain barrier, irreversible kynurenine aminotransferase KAT II inhibitor, with IC50 of 23 and 263 nM for hKATⅡ and rKATⅡ, respectively. PF-04859989 hydrochloride is more selective for KATⅡ than human KATⅠ, KATⅢ and KATⅣ (IC50 is 22, 11 and >50 μM, respectively).
