组织蛋白酶C 来源于牛脾脏

研究领域：细胞信号传导 二肽基肽酶I(DPPI)，又名组织蛋白酶C，是一种含量丰富的溶酶体半胱氨酸蛋白酶，属于木瓜蛋白酶超家族，分子量约200 kDa。[1]广泛表达于各种哺乳动物组织中，在肺、肾、肝和脾中含量最高，大脑中含量相对偏低。 DPPI是其家族中唯一通过四聚体作用的，包含4个相同亚基，每个亚基由N末端片段、一条重链和一条轻链组成。除了用作非特异性溶酶体蛋白酶，它还是一种多功能的蛋白酶加工机器。 应用 该酶已被用于激活大肠杆菌颗粒酶k（Gzmk）前体。颗粒酶是颗粒形式储存的淋巴细胞丝氨酸蛋白酶，其与T和自然杀伤细胞介导的细胞毒性防御反应有关。 牛脾组织蛋白酶C已用于体外酶活性检测。还用作髓鞘少突胶质细胞糖蛋白(MOG)的体外消化酶。 组织蛋白酶C已被用于一项研究中，其证明了蛋白质组学方法的潜力，该方法鉴定出绒毛外滋养层细胞表达的新型蛋白质并揭示导致妊娠疾病的机制。组织蛋白酶C也已被用于评估可生物降解的热凝胶的研究中。 注意 不稳定。保持冷冻。 外形 从1 M氯化钠溶液中冻干获得。 Research Area: Cell Signaling Dipeptidyl peptidase I (DPPI), also known as cathepsin C, is an abundant lysosomal cysteine protease from the papain superfamily with a molecular weight of approximately 200 kDa. It is widely expressed in a variety of mammalian tissues, with the highest levels found in the lungs, kidneys, liver, and spleen, and relatively lower levels in the brain. DPPI is the only member of its family that is functional as a tetramer, consisting of four identical subunits, each composed of an N-terminal fragment, a heavy chain, and a light chain. It is identified as one of the multifaceted protease-processing machines, having been shown to function beyond its role as a non-specific lysosomal protease. Application Cathepsin C from bovine spleen has been used for the in vitro enzyme activity assays.[3] It has also been used as a digestion enzyme for in vitro myelin oligodendrocyte glycoprotein (MOG) digestion. Cathepsin C has been used in a study that demonstrated the potential of a proteomics approach to identify novel proteins expressed by extravillous trophoblast and to uncover the mechanisms leading to disease states in pregnancy. Cathepsin C has also been used in a study to evaluate biodegradable thermogels. The enzyme has been used in the activation of granzyme k (Gzmk) precursor from E. coli. Granzymes are granule-stored lymphocyte serine proteases that are implicated in T- and natural killer cell-mediated cytotoxic defense reactions. Caution Unstable. Keep frozen. Physical form Lyophilized from a 1 M sodium chloride solution.

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