血管紧张素原（Angiotensinogen, AGT）是一种糖蛋白，在健康人群血浆中的浓度为 2.8-7.1 毫克 / 100 毫升。AGT 主要由肝脏产生，同时也在大脑、大动脉、肾脏和脂肪组织中合成。在血浆中，它以单体形式（分子量 55-65 千道尔顿）和高分子量形式（分子量 200-550 千道尔顿）存在。 对于血压正常的非妊娠人群，高分子量形式的 AGT 占循环系统中总 AGT 的 3%。在妊娠前半段，总 AGT 水平会增加 4 倍，而高分子量形式的 AGT 会增加 20 倍。在羊水的总 AGT 中，高达 80% 为高分子量形式。 血管紧张素原是肾素 - 血管紧张素系统（renin-angiotensin system, RAS）的关键组成部分，该系统是调节血压、体液及电解质稳态的强效调控系统。AGT 作为人肾素的作用底物，同时也是血管紧张素 1、2、3、4、1-9、1-7、1-5 及 1-4 的前体分子。此外，AGT 属于丝氨酸蛋白酶抑制剂（SERPIN）家族，但目前尚未发现其具有蛋白酶抑制活性。血浆中的 AGT 水平会受血浆皮质类固醇、雌激素、甲状腺激素及血管紧张素 2 水平的影响而升高。 消光系数：0.92 所用血浆经 FDA 要求的检测显示，乙型肝炎表面抗原（HBsAg）、抗丙型肝炎病毒（抗 - HCV）、抗乙型肝炎核心抗体（抗 - HBc）均为阴性，且抗人类免疫缺陷病毒 1 型和 2 型（抗 - HIV 1 & 2）也为阴性。 Angiotensinogen (AGT) is a glycoprotein found in plasma at a concentration of 2.8-7.1 mg per 100mL in healthy individuals. AGT is produced primarily by the liver but also is synthesized in the brain, large arteries, kidneys and adipose tissue. In plasma it exists as a monomeric form (55-65 kDa) as well as a high molecular mass form (200-550 kDa). In non-pregnant individuals with normal blood pressure, the high molecular mass form accounts for 3% of total circulating AGT. In the first half of pregnancy the total AGT increases by 4-fold and the high molecular mass form increases by 20-fold. Up to 80% of the total AGT in amniotic fluid is the high molecular mass form. Angiotensinogen is an essential component of the renin-angiotensin system, a potent regulator of blood pressure, body fluid and electrolyte homeostasis. It functions as the substrate for human renin and is the precursor molecule for Angiotensins 1,2,3,4, 1-9, 1-7, 1-5 and 1-4. AGT is also a member of the SERPIN family but it is not known to possess protease-inhibitory activity. Levels in plasma are increased by plasma corticosteroid, estrogen, thyroid hormone and angiotensin-2 levels. Extinction Coefficient: 0.92 Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
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血管紧张素原 来源于人血浆
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| Chinese alias | Hypertensinogen, Renin substrate | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | |
| molecular weight | - | Exact mass | BioReagent |
| PSA | - | logp | - |
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