Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). Post-translational: Phosphorylated by TGF-beta type II receptor.
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Recombinant Human EIF3I Protein
CAS number：unknown molecular formula：
overview
compound introduction
Specs
| Chinese alias | 重组人EIF3I蛋白 | 重组人真核翻译起始因子3I蛋白 | ||
| English alias | eIF-3-beta | eIF3 beta | eIF3 p36 | eIF3-beta | eIF3-p36 | eIF3i | EIF3I_HUMAN | EIF3S2 | Eukaryotic translation initiation factor 3 subunit 2 | Eukaryotic translation initiation factor 3 subunit 2 beta | Eukaryotic translation initiation factor 3 subunit | ||
| CAS number | unknown | molecular formula | |
| molecular weight | - | Exact mass | 无载体 |
| PSA | - | logp | - |
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