compound introduction
Pan KRas-IN-1 is a pan KRas inhibitor, can be used for agent resistance in cancer developed with KRas G12C inhibitors In Vitro Pan KRas-IN-1 (example 5) shows high binding capacity to KRas, with IC 50 s of Form:Solid IC50& Target:KRas G12D 9 nM (IC 50 ) KRas G12S 11 nM (IC 50 ) KRas G12C 6 nM (IC 50 ) KRas Q61H 12 mM (IC 50 ) KRas G12V 29 mM (IC 50 ) K-Ras WT 32 nM (IC 50 ) K-Ras G12R 681 nM (IC 50 ) K-Ras G13D 23 nM (IC 50 )
