Lys-[Des-Arg9]Bradykinin TFA, a naturally occurring kinin, is a potent and highly selective bradykinin B1 receptor agonist with a K i of 0.12 nM, 1.7 nM and 0.23 nM for human , mouse and rabbit B1 receptors , respectively. Lys-[Des-Arg9]Bradykinin TFA has low inhibitory activity on B2 receptors In Vitro Lys-[Des-Arg9]Bradykinin is formed by the proteolytic cleavage of bradykinin, exerts its effects through bradykinin B1 receptor (B1R). Lys-[Des-Arg9]Bradykinin (Lda-BK; 10 μM) enhances the secretion of IL-12p70 and inhibits the secretion of IL-12p40 by mature hMo-DCs. Pretreatment with Lys-[Des-Arg9]Bradykinin treatment reduces the migration of mature hMo-DCs toward medium alone, suggesting that Lys-[Des-Arg9]Bradykinin may inhibit the chemokinesis of mature hMo-DCs. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Lys-[Des-Arg9]Bradykinin (1 μg; intra-artenal injection; New Zealand White rabbits) treatment reduces peripheral vascular resistance in LPS-induced rabbits, but the effect is brief (T 1/2 is 118-195 s). MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:Bradykinin B1 Receptor (B1R)
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Lys-[Des-Arg9]Bradykinin TFA
CAS number：2763588-90-3(DMSO) molecular formula：C52H74F3N13O13
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| Chinese alias | Lys-[Des-Arg9]缓激肽 TFA | ||
| English alias | - | ||
| CAS number | 2763588-90-3(DMSO) | molecular formula | C52H74F3N13O13 |
| molecular weight | 1146.22 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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