GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha ( IRE1α ) which can inhibit IRE1α kinase activity and RNase activity with IC 50 s of 20 and 200 nM, respectively. In Vitro GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit IRE1α kinase activity and RNase activity with IC 50 s of 20 and 200 nM, respectively. The increased autophosphorylation of IRE1α could be reduced in a dose-dependent manner by GSK2850163. Increasing concentrations of GSK2850163 are capable of reducing the increased XBP 1 transcriptional activity. Two additional kinases are weakly inhibited by GSK2850163: Ron (IC 50 =4.4 μM) and FGFR1 V561M (IC 50 =17 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 20 nM (IRE1α kinase activity), 200 nM (IRE1α RNase activity)
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GSK2850163
CAS number：2121989-91-9(DMSO) molecular formula：C24H29Cl2N3O
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2121989-91-9(DMSO) | molecular formula | C24H29Cl2N3O |
| molecular weight | 446.41 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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