PF-06471553 is a potent, selective and orally available monoacylglycerol acyltransferase 3 (MGAT3) inhibitor, with an IC 50 of 92 nM. In Vitro PF-06471553 (6f) is a potent and selective monoacylglycerol acyltransferase 3 (MGAT3) inhibitor, with an IC 50 of 92 nM, and shows >160 fold in vitro selectivity for MGAT3 over DGAT1 (IC 50 , >50 μM), DGAT2 (IC 50 , >100 μM), MGAT1 (IC 50 , 14.9 μM), and MGAT2 (IC 50 , 19.8 μM). PF-06471553 exhibits inhibitory activity against MGAT3 in HEK-293 cells with an IC 50 of 205 nM (pIC 50 , 6.69). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo PF-06471553 (200 mg/kg, p.o.) in addition with (DGAT1 and DGAT2) inhibitors shows additional inhibition of glycerol-d5 incorporated triolein in hMGAT3 mice, and with no effect on WT mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 92 nM (MGAT3)
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PF-06471553
CAS number：1808094-07-6(DMSO) molecular formula：C23H25N5O4S
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 1808094-07-6(DMSO) | molecular formula | C23H25N5O4S |
| molecular weight | 467.54 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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