compound introduction
CBP/p300-IN-12 is a potent and selective covalent histone acetyltransferases p300 ( IC 50 of 166 nM) and CBP inhibitor. CBP/p300-IN-12 decreases the levels of H3K27Ac of PC-3 cells (EC 50 of 37 nM). CBP/p300-IN-12 forms a covalent adduct with C1450 In Vitro CBP/p300-IN-12 (Compound 2) shows antiproliferative effect against androgen receptor (AR)-positive LnCaP-FGC cells (EC 50 of 87 nM), while displaying significantly less activity in the AR-negative cell line DU-145 (EC 50 of 1.37 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 166 nM (p300 HAT domain)
