FTO-IN-8 (FTO-43) is a N6-methyladenosine demethylase ( FTO ) (fat mass- and obesity-associated protein) inhibitor with the IC 50 value of 5.5 μM. FTO-IN-8 has anti-cancer cell proliferative activity. In Vitro FTO-IN-8 (FTO-43) (0-50 μM, 24-72 h) inhibits the proliferation of cancer cells with no cytotoxicity to normal colonic cells. FTO-IN-8 (FTO-43) can increase m 6 A and m 6 A m levels and inhibits Wnt/PI3K-Akt signaling in gastric cancer AGS cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: AGS, SNU16, and KATOIII cell lines Concentration: 0-50 μM Incubation Time: 24, 48, 72 hours Result: Inhibited the growth of SNU16, KATOIII and AGS with the EC 50 values of 17.7 μM, 35.9 μM and 20.3 μM, respectively. Form:Oil
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FTO-IN-8
CAS number：2640366-38-5 molecular formula：C19H23ClN2O2
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2640366-38-5 | molecular formula | C19H23ClN2O2 |
| molecular weight | 346.85 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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